Description
A positive allosteric modulator of α7 nAChRs; selective for α7 nAChRs over α3β2- and α4β2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and 5-HT3A receptors (Ki = >30 µM); potentiates ACh-induced currents in Xenopus oocytes expressing human α7 nAChRs (EC50 = ~1 µM); improves sensory gating deficits in a paired auditory stimulus paradigm in mice from 0.1-10 µmol/kg, i.p